The Eagles and 49ers are the final undefeated teams entering the Week 6 NFL schedule, but no team is undefeated against the spread after five weeks. However, there are three franchises winless against the spread this season: the Giants, Broncos and Panthers. The Broncos already lost and failed to cover the spread this week, but can the Giants or Panthers break their streak and overcome the Week 6 NFL odds? The Giants are 15-point underdogs against the Bills in the latest NFL spreads, while the Panthers are 14-point underdogs against the Dolphins. The Giants will be without Daniel Jones (neck) and will turn to Tyrod Taylor to make his first start since Week 13 of the 2021 NFL season. Do any of these sides have an edge when looking into Week 6 NFL bets? All of the Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 6 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 6 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 6 NFL predictions
We can tell you one of the model's strongest Week 6 NFL picks is that the Falcons (-1.5) cover at home against the Commanders. Atlanta is 3-0 at home this season and Desmond Ridder is coming off his best game of the season after completing 28 of 37 passes for 329 yards and a touchdown. Washington faced a struggling quarterback last week in Justin Fields and ended up being exactly what the young signal-caller needed. Fields threw for 282 yards and four touchdowns against Washington in a 40-20 Bears win on Thursday Night Football. Chicago scored on all five of its first-half possessions and in eight of its 11 possessions in the game.
Washington has the second-worst scoring defense in the NFL, allowing 32 points per game on 372.2 yards per game, the eighth-most in the NFL. The model projects these defensive struggles to continue as Atlanta scores 27 points, with Bijan Robinson recording more than 100 total yards as the Falcons cover in 58% of simulations.See which other teams to pick here.
Another one of its Week 6 NFL predictions: The Seahawks (+3) cover the spread on the road versus the Bengals. Seattle has won three straight games and enters off a bye week, during which players had adequate time to recover from previous injuries. In their three straight wins since an opening loss to the Rams, Seattle has won by six, 10, and 21 points. Seattle is also 3-1 against the spread, while Cincinnati is 2-7 against the number in their last nine games dating back to the 2022 season.
Seattle has only surrendered one turnover and is averaging 27.8 points per game this season, sixth in the league. On the other hand, Cincinnati is only averaging 16.6 points per game, fifth worst in the league to this point. On defense, Cincinnati has given up 154 yards per game on the ground, second worst in the NFL, which should be welcome news to the Seahawks' potent running back duo of Kenneth Walker and Zach Charbonnet.See which other teams to pick here.
How to make Week 6 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 6 NFL schedule and revealed a coveted A-rated pick.You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which A-rated pick should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.
Week 6 NFL odds, lines, spreads
Get full NFL picks at SportsLine
Sunday, Oct. 15
Ravens vs. Titans in London (+5, 42.5)
Commanders at Falcons (-1.5, 42.5)
Vikings at Bears (+3, 44)
Seahawks at Bengals (-3, 45.5)
49ers at Browns (+9.5, 36)
Saints at Texans (+1.5, 42.5)
Colts at Jaguars (-4, 44)
Panthers at Dolphins (-14, 47.5)
Patriots at Raiders (-3, 41.5)
Lions at Buccaneers (+3, 42.5)
Cardinals at Rams (-7, 47.5)
Eagles at Jets (+6.5, 42.5)
Giants at Bills (-15, 43.5)
Monday, Oct. 16
Cowboys at Chargers (+1.5, 51)
